Bruch’s membrane and elastin layer thickness.

<p>(A) EM micrograph of Bruch’s membrane in a BALB/C mouse retina at an eccentricity of 40°. BM, Basement membrane; OC, Outer collagenous layer; EL, Elastin layer; ICL, Inner collagenous layer. Scale bar = 1 μm. (B, D) Graphs of the thickness of the entire Bruch’s membrane in relation to eccentricity in mouse and human retinas. (C, E) Graphs of the thickness of the elastin layer of Bruch’s membrane in relation to eccentricity in mouse and human retinas. The thickness of Bruch's membrane as well as the elastin layer varied very significantly between retinal eccentricities in both mouse strains (<i>P</i> < 0.0001; Tukey’s test). Error bars indicate SEM. The human data, shown in D and E, are from Newsome et al. [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0125631#pone.0125631.ref018" target="_blank">18</a>].</p>