Both C003 and C052 protects BSR cells from BTV induced CPE/apoptosis.

In mock infected BSR cells (A), cells formed a monolayer with no cells detached from the plates. At 72 h.p.i., BTV infected cells showed CPE/apoptosis and were detached from the plate (B). When C003 at 10 µM was added to the BSR cells without BTV infection, there were no obvious changes in term of cell morphology (C). There were also no morphology changes when cells were treated with C003 and with BTV infection (D). Similarly, when C052 at 2.5 µM was added to the BSR cells without BTV infection, there were no cytotoxicity (E), and C052 could also block BTV-induced CPE/apoptosis (F).