Bortezomib significantly reduced growth plate height.

<p>Representative pictures of mouse tibia growth plates on day 13 (<b>A</b>) and at termination of the experiment on day 56 (<b>B</b>). The thin black lines indicate the different zones within the growth plate; R (resting), P (proliferative) and H (hypertrophic). Bars, 100 µm. Quantitative analyses of growth plate height on day 13 (<b>C</b>) and on day 56 (<b>D</b>) within the tibia growth plates of vehicle- and bortezomib treated C57B and NMRI mice, n = 6 per group. Data represent mean±SEM; **p<0.01, ***p<0.001 vs. corresponding strain of vehicle treated mice.</p>