Bortezomib significantly reduced growth plate height.

Representative pictures of mouse tibia growth plates on day 13 (A) and at termination of the experiment on day 56 (B). The thin black lines indicate the different zones within the growth plate; R (resting), P (proliferative) and H (hypertrophic). Bars, 100 µm. Quantitative analyses of growth plate height on day 13 (C) and on day 56 (D) within the tibia growth plates of vehicle- and bortezomib treated C57B and NMRI mice, n = 6 per group. Data represent mean±SEM; **p<0.01, ***p<0.001 vs. corresponding strain of vehicle treated mice.