Table_1.xls (5.5 kB)

Bivariate GCTA estimates of the genetic and residual correlations for bone mineral density measurements at the total-body less head, lower limb, upper limb and skull for the ALSPAC cohort.

dataset

posted on 2014-06-19, 03:23 authored by John P. Kemp, Carolina Medina-Gomez, Karol Estrada, Beate St Pourcain, Denise H. M. Heppe, Nicole M. Warrington, Ling Oei, Susan M. Ring, Claudia J. Kruithof, Nicholas J. Timpson, Lisa E. Wolber, Sjur Reppe, Kaare Gautvik, Elin Grundberg, Bing Ge, Bram van der Eerden, Jeroen van de Peppel, Matthew A. Hibbs, Cheryl L. Ackert-Bicknell, Kwangbom Choi, Daniel L. Koller, Michael J. Econs, Frances M. K. Williams, Tatiana Foroud, M. Carola Zillikens, Claes Ohlsson, Albert Hofman, André G. Uitterlinden, George Davey Smith, Vincent W. V. Jaddoe, Jonathan H. Tobias, Fernando Rivadeneira, David M. Evans

TBLH-BMD = total body less head BMD, (LL-BMD) = lower limb BMD, (UL-BMD) = upper limb BMD, (SK-BMD) = skull BMD, r_g = genetic correlation between trait 1 and trait 2. r_e = residual correlation between trait 1 and trait 2. All traits, excluding SK-BMD were adjusted for age, gender and weight. SK-BMD was adjusted for age, gender and height. P-refers to the P-value for the likelihood ratio test of whether r_g = 0. Phenotypic correlations (r_p) were as follows: SK-BMD/TBLH-BMD (r_p = 0.40, SE = 0.013, P<0.001), SK-BMD/LL-BMD (r_p = 0.31, SE = 0.013, P<0.001), SK-BMD/UL-BMD (r_p = 0.40, SE = 0.013, P<0.001) and LL-BMD/UL-BMD (r_p = 0.64, SE = 0.010, P<0.001).