Biomarker networks of immune system from cynomolgus macaques naturally infected with T. cruzi (CH) and non-infected controls (NI).

Circular layouts were built to underscore the relevant associations between cell subsets, the expression of adhesion molecules, cytotoxicity markers, and the activation/regulatory status, using a clustered distribution of nodes for innate (left side) and adaptive (right side) immunity cells. The overall statistical analysis of the network node neighborhood connections points out to a uniform pattern in non-infected controls and a clear shift towards a bimodal profile in T. cruzi-infected hosts, with prominent involvement of adaptive immunity events.