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Biomarker networks of immune system from cynomolgus macaques naturally infected with T. cruzi (CH) and non-infected controls (NI).

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posted on 28.01.2016 by Renato Sathler-Avelar, Danielle Marquete Vitelli-Avelar, Armanda Moreira Mattoso-Barbosa, Marcelo Perdigão-de-Oliveira, Ronaldo Peres Costa, Silvana Maria Elói-Santos, Matheus de Souza Gomes, Laurence Rodrigues do Amaral, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Edward J. Dick Jr, Gene B. Hubbard, Jane F. VandeBerg, John L. VandeBerg

Circular layouts were built to underscore the relevant associations between cell subsets, the expression of adhesion molecules, cytotoxicity markers, and the activation/regulatory status, using a clustered distribution of nodes for innate (left side) and adaptive (right side) immunity cells. The overall statistical analysis of the network node neighborhood connections points out to a uniform pattern in non-infected controls and a clear shift towards a bimodal profile in T. cruzi-infected hosts, with prominent involvement of adaptive immunity events.

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