Figure_5.tif (2.44 MB)
Beta cell adaptation in islets grafts from different pancreatic regions transplanted in syngeneic diabetic mice.
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posted on 2013-02-18, 02:14 authored by Johanne H. Ellenbroek, Hendrica A. Töns, Natascha de Graaf, Cindy J. Loomans, Marten A. Engelse, Hans Vrolijk, Peter J. Voshol, Ton J. Rabelink, Françoise Carlotti, Eelco J. de KoningA. Average islet size per transplant. B. Blood glucose concentrations of STZ-induced diabetic mice followed up to 10 days after transplantation (n = 6–8 mice per region) of DR, GR or SR islets. C. AUC blood glucose concentrations post-transplantation corrected for pre-transplantation glucose concentration (n = 6–8 mice per region). D. Image of proliferating beta-cells, positive for both BrdU (brown) and insulin (red) in islets transplanted under the kidney capsule of diabetic mice. Scale bar = 20 µm. E. Beta cell proliferation in the islet grafts 10 days after transplantation, BrdU labeling during the final 7 days (n = 6–7 mice per region). DR = duodenal region, GR = gastric region, SR = splenic region, AUC = area under the curve.
