BPA treatment leads to increased IRS-1 protein in basal conditions and alters insulin signaling in insulin stimulated conditions in the liver.
figure
posted on 2012-03-28, 00:45 authored by Thiago M. Batista, Paloma Alonso-Magdalena, Elaine Vieira, Maria Esmeria C. Amaral, Christopher R. Cederroth, Serge Nef, Ivan Quesada, Everardo M. Carneiro, Angel Nadal(A) Total IRS-1 protein expression (n = 4). (B) Akt protein expression (n = 5). α-tubulin was used as an internal control. (C) IR tyrosine phosphorylation (n = 5–7), (D) Akt phosphorylation (Ser473) (n = 5–7), (E) Akt phosphorylation (Thr308) (n = 5–7), (F) ERK1/2 phosphorylation (n = 4–7). Statistical differences were determined by Student's t test *, p<0.05. Data are expressed as mean ±S.E.M.
