Averages and standard deviations of main pocket and ligand descriptors for the five clusters a, b, c, d and e.

For the five clusters, if the corresponding analysis of variance and the Tukey’s HSD test are significant, a vertical line between two clusters is drawn. No vertical line means that the test is not significant i.e. the p-value is more than 0.05. One, two or three vertical lines mean that the test is significant and that: 0.01≤p-value≤0.05 for one vertical line, 0.001≤p-value≤0.01 for two vertical line or p-value≤0.001 for three vertical lines.