Antibody binding kinetic constants to selected MPER probes.

a

MPER peptide: EQELLELDKWASLWNWFDITKWLWYIKKKKGSKKK.

b

Linked peptide: EQELLELDKWASLGGGGSGGWNWFDITKWLWYIKKKKGSKKK.

c

ES2 scaffold: scaffold protein displaying the 2F5 gp41 epitope stabilized in the antibody-bound conformation.

d

Association rate (k_on) is measured in (1/Ms 10⁵).

e

Dissociation rate (k_off) is measured in (1/s 10⁻³).

f

Affinity constant (KD) is measured in (M 10⁻⁹ or nM).