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Anchorage-dependent, -independent growth and formation of lung metastases.
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posted on 2015-04-17, 02:57 authored by Petra A. Tsuji, Bradley A. Carlson, Min-Hyuk Yoo, Salvador Naranjo-Suarez, Xue-Ming Xu, Yiwen He, Esther Asaki, Harold E. Seifried, William C. Reinhold, Cindy D. Davis, Vadim N. Gladyshev, Dolph L. Hatfield(A) Growth rates of shSep15, shTR1 and shTR1/Sep15 cells compared to controls (n = 6). (B) Anchorage-independent growth in soft agar of shSep15, shTR1 and shTR1/Sep15 cells compared to controls (n = 4–8). (C) Formation of experimental lung metastases after i.v. injection of 5×105 cells (control, shSep15, shTR1, or shTR1/shSep15) into BALB/c mice (n = 10/construct). (***P<0.001, compared to control).
