Anatabine reduces the amount of phosphorylated p65 NFκB immunopositive cells associated with β-amyloid deposits in the cortex of Tg PS1/APPswe mice.

A) Representative 40X microscopic field revealing the presence of phosphorylated p65 NFκB immunopositive cells around Congo red stained β-amyloid deposits in the cortex of Tg PS1/APPswe mice receiving regular drinking water (placebo) or anatabine at a dosage of 10 and 20 mg/Kg/Day in their drinking water. Data is presented as mean±SEM. B) The histogram represents the average amount of phospho p65 NFκB burden (expressed as a percentage of the brain area examined) associated with β-amyloid deposits in the cortex Tg PS1/APPswe receiving regular drinking water (placebo) and the anatabine treatment at a dosage of 10 and 20 mg/Kg/Day. ANOVA shows a statistically significant main effect of the anatabine treatment on phosphorylated p65 NFκB immunoreactive cells associated with Aβ deposits (P<0.001). Post-hoc comparisons reveal statistically significant differences between Tg PS1/APPswe receiving regular drinking water (placebo) and anatabine at a dosage of 10 mg/Kg/Day (P<0.001) and 20 mg/Kg/Day (P<0.001) for the amount of p65 NFκB phosphorylation associated with β-amyloid burden.