Anatabine reduces β-amyloidosis in the hippocampus and the cortex of Tg PS1/APPswe mice.

A) Representative 20X microscopic fields showing β-amyloid deposits (4G8 immunostaining) in the cortex and hippocampus of Tg PS1/APPswe receiving regular drinking water (placebo) and anatabine at a dosage of 10 and 20 mg/Kg/Day dissolved in their drinking water are shown. Data is presented as mean±SEM. B) The histogram represents the average amount of 4G8 burden quantified in the hippocampus and cortex of Tg PS1/APPswe mice. ANOVA shows a statistically significant main effect of the anatabine treatment (P<0.001) on β-amyloid plaque burden. Post-hoc analyses reveal statistically significant differences in β-amyloid burden in the hippocampus (P<0.002 and P<0.001) and cortex (P<0.001 and P<0.001) between Tg PS1/APPswe mice receiving regular drinking water (placebo) and Tg PS1/APPswe receiving anatabine at a dosage of 10 and 20 mg/Kg/Day dissolved in their drinking water.