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Adoptive transfer of iTreg cells altered cytokine production.

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posted on 2013-02-20, 02:51 authored by Wei Xu, Qin Lan, Maogen Chen, Hui Chen, Ning Zhu, Xiaohui Zhou, Julie Wang, Huimin Fan, Chun-Song Yan, Jiu-Long Kuang, David Warburton, Dieudonnée Togbe, Bernhard Ryffel, Song-Guo Zheng, Wei Shi

(A) iTreg cells inhibited OVA-induced increase of Th2 cytokines. IL-5 and IL-13 in mouse serum were quantified by specific ELISA. Significant reduction of IL-5 and IL-13 in the group receiving iTreg treatment was detected compared to OVA challenge only control group. **P<0.01. (B) Expression of IRF-4 and IL-10 at the mRNA level of lung lymphocytes was significantly increased in iTreg-treated OVA mice compared to untreated OVA mice. *P<0.05.

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