Adoptive transfer of iTreg cells altered cytokine production.
(A) iTreg cells inhibited OVA-induced increase of Th2 cytokines. IL-5 and IL-13 in mouse serum were quantified by specific ELISA. Significant reduction of IL-5 and IL-13 in the group receiving iTreg treatment was detected compared to OVA challenge only control group. **P<0.01. (B) Expression of IRF-4 and IL-10 at the mRNA level of lung lymphocytes was significantly increased in iTreg-treated OVA mice compared to untreated OVA mice. *P<0.05.