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Activation of mouse splenocytes by CpG-ODN developed for rabbits.

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posted on 2014-09-30, 02:58 authored by Tsung-Hsien Chuang, Chao-Yang Lai, Ping-Hui Tseng, Chiun-Jye Yuan, Li-Chung Hsu

Mouse splenocytes were stimulated with 2µM of different CpG-ODN: CpG-2006 and CpG-2007, optimized for humans; CpG-1826, optimized for mice; and CpG-C46 and CpG-C4609, developed for rabbits. Induction of (A) IL-6 and (B) IFN-γ, and production of (C) IgM, were determined by ELISA. Data shown represent mean ± SD (n = 3 independent experiments). *P<0.05 vs. the induction by CpG-1826.

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