Activation of mouse splenocytes by CpG-ODN developed for rabbits.

Mouse splenocytes were stimulated with 2µM of different CpG-ODN: CpG-2006 and CpG-2007, optimized for humans; CpG-1826, optimized for mice; and CpG-C46 and CpG-C4609, developed for rabbits. Induction of (A) IL-6 and (B) IFN-γ, and production of (C) IgM, were determined by ELISA. Data shown represent mean ± SD (n = 3 independent experiments). *P<0.05 vs. the induction by CpG-1826.