Activation of antigen-specific immune responses by CpG-ODN developed for rabbits.

Rabbits were immunized with 100µg of RHDV NJ85 peptide mixed with or without 50µg of CpG-ODN, as indicated. (A) The cycle of immunization and serum collection followed a 14-day-interval schedule, as shown. (B) Inductions of IFN-γ from CD8 T cells by NJ85 were measured by ELISA. (C) Titers of anti-NJ85 antibody in serum samples were measured by ELISA. Data shown represent mean ± SD (n = 3 independent experiments). *P<0.05 vs. the induction by CpG-C4609.