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Accumulation of ubiquitin in mutant FUS transgenic rats.

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posted on 2011-03-03, 01:13 authored by Cao Huang, Hongxia Zhou, Jianbin Tong, Han Chen, Yong-Jian Liu, Dian Wang, Xiaotao Wei, Xu-Gang Xia

(A–L) Double-fluorescence staining revealed accumulation of ubiquitin in the cortex (D–F) and spinal cord (J–L) of the mutant FUS transgenic rats (line 16) at paralysis stages, but not in tissues of the age-matched normal FUS transgenic rats (line 20) (A–C: cortex; G–I: spinal cord). Coronal sections of the frontal cortex and traverse sections of the lumbar cord were immunostained with antibodies to ubiquitin (green) and human FUS (red). Scale bars: A–F, 20 µm.

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