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A possible dual role for Wnt in the maintenance of stem cell niches.

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posted on 2007-09-26, 01:24 authored by Zach Klapholz-Brown, Graham G. Walmsley, Ysbrand M. Nusse, Roel Nusse, Patrick O. Brown

We hypothesize that Wnt may promote self-renewal directly by raising nuclear ß-Catenin levels in stem cells and indirectly by activating the BMP inhibitor Gremlin 2 in nearby fibroblasts, thereby blocking target BMPs from promoting differentiation and loss of self-renewal capacity.

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