A model of evolution of the PhoP BSs based on submotifs.

<p>Rate of evolution calculated by nucleotide substitutions at each position of the PWMs corresponding to submotifs using the HB model (blue) <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1000862#pcbi.1000862-Moses1" target="_blank">[18]</a>, <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1000862#pcbi.1000862-Moses2" target="_blank">[19]</a>, compared with the background distributions using the HKY model (red) <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1000862#pcbi.1000862-Moses1" target="_blank">[18]</a>, <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1000862#pcbi.1000862-Moses2" target="_blank">[19]</a> based on randomly selected non-coding sequences from <i>E. coli</i> K-12 and <i>S. typhimurium</i> genomes. The information content (green) is inversely correlated to the rate of evolution of submotifs. <b>A</b>) Low rates of evolution of the S01 submotif. <b>B</b>) High rates of evolution of S05 submotif. <b>C</b>) Rates of evolution of single motif. <b>D</b>) Same as in <b>A</b>), but using an AT rich non-coding intergenic regions in the background model. <b>E</b>) Same as <b>B</b>), but using an AT rich non-coding intergenic regions in the background model. <b>F</b>) Same as <b>C</b>), but using an AT rich non-coding intergenic regions in the background model.</p>