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A Thr668Ala mutation on APP prevents the synaptic deficits of FDDKI mice.

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posted on 2013-02-23, 11:25 authored by Franco Lombino, Fabrizio Biundo, Robert Tamayev, Ottavio Arancio, Luciano D’Adamio

Normal LTP in FDDKI/APPTA/TA and APPTA/TA compared with WT mice by two-way ANOVA (FDDKI/APPTA/TA versus WT mice: F(1,12) = 1.936; P = 0.187; APPTA/TA versus WT F(1,12) = 0.989; P = 0.338). Two-way ANOVA shows impaired LTP in FDDKI mice when compared with WT (F(1,13) = 15.125; P = 0.002), to FDDKI/APPTA/TA (F(1,13) = 12.759; P = 0.004) or to APPTA/TA mice littermates (F(1,13) = 22.396; P<0.0001).

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