A Thr<sup>668</sup>Ala mutation on APP prevents the synaptic deficits of FDD<sub>KI</sub> mice.

<p>Normal LTP in FDD<sub>KI</sub>/<i>APP<sup>TA/TA</sup></i> and <i>APP<sup>TA/TA</sup></i> compared with WT mice by two-way ANOVA (FDD<sub>KI</sub>/<i>APP<sup>TA/TA</sup></i> versus WT mice: F(1,12) = 1.936; P = 0.187; <i>APP<sup>TA/TA</sup></i> versus WT F(1,12) = 0.989; P = 0.338). Two-way ANOVA shows impaired LTP in FDD<sub>KI</sub> mice when compared with WT (F(1,13) = 15.125; P = 0.002), to FDD<sub>KI</sub>/<i>APP<sup>TA/TA</sup></i> (F(1,13) = 12.759; P = 0.004) or to <i>APP<sup>TA/TA</sup></i> mice littermates (F(1,13) = 22.396; P<0.0001).</p>