AKT pathway model.

2014-08-04T03:12:40Z (GMT) by Yohei Murakami

(A) Structure of the AKT pathway model. The input signal is insulin. The output signal is pAKT. Solid arrows represent mass flows. Solid arrows directional to a lined circle represent degradation processes. Solid arrows with black circles represent association/dissociation processes. Dotted arrows represent enhancement of the processes. (B) Experimental data (red points) and simulated trajectory (green trajectory) of pAKT in response to the step stimulation of 1 nM insulin. (C), (D), (E) Reproduction of the experimental data. Simulations were run with the posterior parameter ensemble in response to the step stimulation of 1 nM insulin. (C) Annealing schedule: (ε0, ε1, ε2, ε3, ε4, ε5, ε6, ε7, ε8, ε9, ε10, ε11, ε12, ε13, ε14) = (∞, 1.5, 1.0, 0.75, 0.5, 0.25, 0.1, 0.09, 0.08, 0.07, 0.06, 0.05, 0.04, 0.03, 0.02). (D) Annealing schedule: (ε0, ε1, ε2, ε3, ε4, ε5, ε6, ε7, ε8, ε9, ε10, ε11, ε12, ε13, ε14, ε15) = (∞, 1.5, 1.0, 0.75, 0.5, 0.25, 0.1, 0.09, 0.08, 0.07, 0.06, 0.05, 0.04, 0.03, 0.02, 0.01). (E) Annealing schedule: (ε0, ε1, ε2, ε3, ε4, ε5, ε6, ε7, ε8, ε9, ε10, ε11) = (∞, 1.5, 1.0, 0.75, 0.5, 0.25, 0.1, 0.09, 0.08, 0.07, 0.06, 0.05). Blue-colored area is the probability density consists of the simulated trajectories. Red points are the experimental data.