Figure_6.tif (378.59 kB)
5-HT3A CNiFER: Ondansetron antagonism.
figure
posted on 2013-02-20, 20:58 authored by John G. Yamauchi, Ákos Nemecz, Quoc Thang Nguyen, Arnaud Muller, Lee F. Schroeder, Todd T. Talley, Jon Lindstrom, David Kleinfeld, Palmer TaylorA. Competitive blockade of 5-HT elicited responses on 5-HT3A CNiFERs by ondansetron. The steep Hill coefficient of 2.6 shows the more cooperative nature of the 5-HT3A receptor. The EC50 values for each curve shifted from 220 nM to 1.6 µM, 2.6 µM, and 4.5 µM for 5 nM, 10 nM, 15 nM ondansetron respectively. B. Schild plot of concentration dependent shifts. A slope of -1.3±0.04 confirmed ondansetron to block competitively.
