ol9b01933_si_001.pdf (9.83 MB)
[3 + 2]-Annulation of Azaoxyallyl Cations and Thiocarbonyls for the Assembly of Thiazolidin-4-ones
journal contribution
posted on 2019-07-11, 19:45 authored by Vandana Jaiswal, Biplab Mondal, Kuldeep Singh, Dinabandhu Das, Jaideep SahaA base-promoted,
efficient [3 + 2] annulation between azaoxyallyl
cations and thiocarbonyls is reported for flexible access to highly
functionalized thiazolidin-4-one derivatives in good to excellent
yields. An intriguing feature of this method is the metal or Lewis
acid free late-stage entry of distinct set of functional groups at
C2 of thiazolidin-4-ones via substitution of a latent amino functional
group. Overall, this approach constitutes a general platform for convenient
access to this medicinally important scaffold.