ß-catenin increases HERG current.
A. Original tracings recorded in oocytes injected with H20 (1), with cRNA encoding HERG (2) or HERG coexpressing ß-catenin (3). The oocytes were depolarized from −80 mV holding potential to different voltages followed by a 500 ms pulse to −60 mV evoking outward tail currents. The small insert displays the applied voltage protocol. B. Arithmetic means±SEM (n = 8–11) of the normalized outward tail current following a depolarization to +80 mV recorded in oocytes injected with H20 (left bar), with cRNA encoding HERG (middle bar) or with RNA encoding HERG and ß-catenin (right bar). * indicates statistical significance (p<0.05) from the absence of ß-catenin cRNA. C. IV curves of outward tail currents illustrated in B (upper panel) and IV curves of outward tail currents following normalization to the maximal tail current of the respective group (lower panel).