jo8019797_si_001.pdf (9.82 MB)
Zinc-Mediated Allylation and Alkylation of Aminals in the Presence of TMSCl and Diisopropylamine
journal contribution
posted on 2008-11-21, 00:00 authored by Bunpei Hatano, Keita Nagahashi, Tatsuro KijimaAn alkylation of aminals with organozinc reagents derived from allyl bromide, benzyl bromide, α-bromoacetate, and α-bromonitrile proceeded efficiently in the presence of TMSCl and diisopropylamine. This reaction system was applied to the synthesis of an antispasmodic: butaverine.