Workflow of visualization of metabolic networks and associated data.

This chart describes the flow of data inputs and analyses in VisANT 5.0, with focus on functionalities which help interpret community-level models of microbial metabolism. VisANT 5.0 integrates three main data types (top pink layer) pertaining to ecosystem-level metabolism: (i) One or more stoichiometric models of metabolic networks for different organisms; (ii) Flux data for all reactions in all organisms at different time points; (iii) A layout file where spatial information of metabolic models is specified. Adding these different types of information on top of each other leads to visualization of different features of the network (gray layer). These networks can be combined with additional knowledge on the catalyzing enzymes, such as regulatory effects or protein-protein interaction edges (bottom layer, green).