Viability curves of H2452 and MSTO cells treated with pemetrexed, cisplatin, and cSBL, either alone or in combination.

Each group of cells was treated with fixed concentration ratios of pemetrexed:cisplatin:cSBL as follows: 800:100:1 (for H2452 cells) or 3:20:2 (for MSTO cells). Each data point represents the mean ± SD of at least three independent WST-8 assays. Each sample was plated in triplicate. The y-axis indicates the viability of cells. The x-axis indicates the concentration of pemetrexed (upper), cisplatin (middle), or cSBL (lower).