Various oncogenes in triple-negative breast cancer (TNBC).

<p>(<b>A</b>) NFKB1 mutations found in this study (above, TNBC) and in the TCGA data (below, various cancers). (<b>B</b>) Mutations in NOTCH1 found in this study (above, TNBC) and in the TCGA data (below, TNBC). (<b>C</b>) Mutations in ERBB2 found in this study (above, TNBC) and in the TCGA data (below, BC). (<b>D</b>) Diagram of the protein encoded by the <i>FGFR3</i>-<i>CAT</i> fusion gene. IG, immunoglobulin-like domain; TyrKc, tyrosine-protein kinase catalytic domain. (<b>E</b>) Anchorage-independent growth of 3T3 cells expressing the indicated proteins. The diagrams of the proteins in (<b>A</b>), (<b>B</b>), and (<b>C</b>) were generated using protein painter (<a href="http://explore.pediatriccancergenomeproject.org/proteinPainter" target="_blank">http://explore.pediatriccancergenomeproject.org/proteinPainter</a>). Mutations expected to be activating according to previous reports or experiments in this study are highlighted in red.</p>