IJFP-2332-287X-03-002e.pdf (530.68 kB)
Variant Translocation of ETV6 and RUNX1 in a Case of Pediatric Acute Lymphoblastic Leukemia
journal contribution
posted on 2017-12-05, 12:30 authored by Yenamandra A, Hollis A, McManus MRearrangement of ETV6 (or TEL) gene at chromosome 12p13
region has been reported in several hematopoietic malignancies.
About 25% of pediatric B cell Acute Lymphoblastic leukemia (BALL)
cases have t(12;21) translocation involving ETV6 locus at
12p13 and RUNX1 locus at 21q22 (1, 2) and is associated with a
good event free survival. Many of these cases may have additional
aberrations in addition to poor morphology. Variant and complex
translocations of t(12;21) involving an additional chromosome
have been reported in several cases of ALL