VHL and Related Molecular Mechanisms in Renal Cell Carcinomas

Tumorigenesis of renal cell carcinomas
- Oxygen plays a central role in renal cell tumorigenesis.
- Reactive oxygen species, mitochondria, apoptosis and angiogenesis are the action processes and targets involved
- Renal cell carcinoma is essentially the consequence of a genetically-mediated metabolic disease
- Intratumor heterogeneity is the byproduct of progression and a constant finding expressing random selection (evolutionary biology)