V67A and P145A disrupted the co-localization between NS5A and Core or LDs.

A Quantification of the percentages of NS5A colocalized with LD (white blocks), or LD colocalised with NS5A (red blocks). B Quantification of the percentages of NS5A colocalized with Core (white blocks), or Core colocalised with NS5A (green blocks). C Quantification of the percentages of Core colocalized with LD (green blocks), or LD colocalised with Core (red blocks). D Spatial data for the distance of LDs from the nuclear envelope were determined from 10 cells for each construct using Fiji. **** indicates significant difference (P<0.0001) from the results for WT.