op7b00180_si_001.pdf (179.76 kB)
Use of Catalytic Static Mixers for Continuous Flow Gas–Liquid and Transfer Hydrogenations in Organic Synthesis
journal contribution
posted on 2017-06-28, 00:00 authored by Christian H. Hornung, Xuan Nguyen, Antony Carafa, James Gardiner, Andrew Urban, Darren Fraser, Mike D. Horne, Dayalan R. Gunasegaram, John TsanaktsidisCatalytic
static mixers were used for the continuous flow hydrogenation of alkenes,
alkynes, carbonyls, nitro- and diazo-compounds, nitriles, imines,
and halides. This technique relies on tubular reactors fitted with
3D printed static mixers which are coated with a catalytic metal layer,
either Pd or Ni. Additive manufacturing of the metal mixer scaffold
results in maximum design flexibility and is compatible with deposition
methods such as metal cold spraying which allow for mass production
and linear process scale up. High to full conversion was achieved
for the majority of substrates, demonstrating the flexibility and
versatility of the catalytic static mixer technology. In the example
of an alkyne reduction, the selectivity of the flow reactor could
be directed to either yield an alkene or alkane product by simply
changing the reactor pressure.