Upstream regulators significantly affected in the lesions.

(A) List of known regulators that demonstrated significant expression changes and affected the expression of its known downstream target genes. “pv” = p-value, “n” = number of known target genes changed in lesions, “fold” = expression changes for the regulator, “Z” = z-score for the predicted change of the regulator activity. (B) Top regulator network discovered by Ingenuity Pathway analysis with IFNA predicted to be activated, resulting in expression changes of the CXCL9, 10 and 11 that mainly activate multiple blood-related functions.