Unusual Course of the Reaction of Allyl Phosphine Oxides with the Grundmann Ketone

2014-08-25T13:59:32Z (GMT) by Katarzyna Sokolowska Rafal R. Sicinski
<div><p></p><p>This article describes efficient preparation of isomeric allyl phosphine oxides possessing a protected cyclohexanediol fragment. Their base-catalyzed interconversions are examined and reactions with the Grundmann ketone provide an adduct containing the rearranged vinyl phosphine oxide moiety, instead of 19-norvitamin D<sub>3</sub> analogs, the expected products of the Horner–Wittig process.</p> </div>