lsyc_a_909491_sm5906.pdf (1.9 MB)
Unusual Course of the Reaction of Allyl Phosphine Oxides with the Grundmann Ketone
Version 4 2014-08-25, 13:59
Version 3 2014-08-25, 13:59
Version 2 2014-08-18, 14:07
Version 1 2014-08-25, 13:59
journal contribution
posted on 2014-08-25, 13:59 authored by Katarzyna Sokolowska, Rafal R. SicinskiThis article describes efficient preparation of isomeric allyl phosphine oxides possessing a protected cyclohexanediol fragment. Their base-catalyzed interconversions are examined and reactions with the Grundmann ketone provide an adduct containing the rearranged vinyl phosphine oxide moiety, instead of 19-norvitamin D3 analogs, the expected products of the Horner–Wittig process.