lsyc_a_1324626_sm2013.docx (290.85 kB)
Ultrasound-assisted synthesis of 2-amino-1,3,4-oxadiazoles through NBS-mediated oxidative cyclization of semicarbazones
Version 2 2017-06-07, 15:46
Version 1 2017-05-05, 18:02
journal contribution
posted on 2017-06-07, 15:46 authored by Ana Flávia Borsoi, Mateus Emanuel Coldeira, Kenia Pissinate, Fernanda Souza Macchi, Luiz Augusto Basso, Diógenes Santiago Santos, Pablo MachadoA ultrasound-assisted oxidative cyclization of semicarbazones using N-bromosuccinimide in the presence of sodium acetate was established providing efficient and rapid access to a variety of 2-amino-1,3,4-oxadiazoles. Moreover, the new synthetic protocol provides a simple procedure utilizing a safer oxidizing system that affords the target products in high regioselectivity, satisfactory yields, and elevated purities.
