Two novel compounds from the root bark of <i>Morus alba</i> L.

<p>Chemical investigation of the root bark of <i>Morus alba</i> led to the isolation of a new flavone, dioxycudraflavone A (<b>1</b>) and a new 2-arylbenzofuran, 5-hydroxyethyl moracin M (<b>2</b>), together with seven known compounds namely sanggenon V (<b>3</b>), morusin (<b>4</b>), morusignin L (<b>5</b>), licoflavone C (<b>6</b>), moracin C (<b>7</b>), alfafuran (<b>8</b>) and mulberrofuran G (<b>9</b>). The structure elucidation of these compounds was based on analyses of spectroscopic data including 1D, 2D NMR and HR-ESI-MS. All compounds were evaluated for the α-glucosidase inhibitory and cytotoxic activities. Compounds <b>2</b>–<b>4</b>, <b>8</b> and <b>9</b> exhibited strong α-glucosidase inhibitory activities with IC<sub>50</sub> less than 10 μM, while only <b>4</b> and <b>9</b> showed moderate cytotoxic effects against lung cancer cells.</p>