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Two new sesquiterpenes derivatives from marine fungus Leptosphaerulina Chartarum sp. 3608

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journal contribution
posted on 2017-11-27, 06:14 authored by Panpan Zhang, Jing Li, Jiajia Lang, Chunxiu Jia, Shah-Iram Niaz, Senhua Chen, Lan Liu

Two new sesquiterpenes, leptoterpenes A (1) and B (2) were isolated from the fungus Leptosphaerulina Chartarum sp. 3608, derived from a crinoid. It was the first chemical study on this species. The structures of these compounds were elucidated by spectroscopic methods including NMR and MS spectrometry. The absolute configurations of the new compounds were determined on the basis of the single-crystal X-ray diffraction and electronic circular dichroism data analysis. All compounds were tested for their anti-inflammatory activity and the inhibitory effects on Tyrosyl DNA phosphodiesterase II (TDP2).

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