Two new phenylspirodrimanes from the deep-sea derived fungus Stachybotrys sp. MCCC 3A00409

Ma, Xin-hua; Zheng, Wei-min; Sun, Kai-hui; Gu, Xiao-fan; Zeng, Xian-ming; Zhang, Hai-tao; Zhong, Tian-hua; Shao, Zong-ze; Zhang, Yong-hong

doi:10.6084/m9.figshare.6021788.v1

gnpl_a_1455041_sm7347.pdf (2.04 MB)

Two new phenylspirodrimanes from the deep-sea derived fungus Stachybotrys sp. MCCC 3A00409

journal contribution

posted on 2018-03-23, 11:25 authored by Xin-hua Ma, Wei-min Zheng, Kai-hui Sun, Xiao-fan Gu, Xian-ming Zeng, Hai-tao Zhang, Tian-hua Zhong, Zong-ze Shao, Yong-hong Zhang

Two new phenylspirodrimanes, stachybotrin H (1) and stachybotrysin H (9) together with eleven known analogues (2–8, 10–13) were isolated from deep-sea derived Stachybotrys sp. MCCC 3A00409. Their structures were determined by extensive NMR data and mass spectroscopic analysis. Compounds 9–12 showed weak cytotoxicity against three human cancer cell lines K562, Hela and HL60 with IC₅₀ in the range of 18.5–52.8 μM.