gnpl_a_1413566_sm7455.pdf (1.18 MB)
Two new compounds from Nigrospora sphaerica ZMT05, a fungus derivated from Oxya chinensis Thunber
journal contribution
posted on 2017-12-18, 16:51 authored by Xinwei Zhu, Jiaqing Chen, Shuirong Zhu, Yuyi He, Weijia Ding, Chunyuan LiA new pyrrolidinone derivative named nigrosporamide A (1), and a new acetophenone derivative, 4-prenyloxyclavatol (2), were isolated from an endophytic fungus Nigrospora sphaerica (collection No. ZMT05) isolated from Oxya chinensis Thunberg. Their chemical structures were established on the basis of the interpretation of spectroscopic data. In primary in vitro bioassay, nigrosporamide A (1) exhibited strong antifungal activity against Colletotrichum gloeosporioides and high inhibitory activity towards α-glucosidase.