Two new clerodane-type diterpenoids from Bornean liverwort <i>Gottschelia schizopleura</i> and their cytotoxic activity

<p>The Bornean liverwort <i>Gottschelia schizopleura</i> was investigated phytochemically for the first time. Two new and four previously known clerodane-type diterpenoids were isolated from the MeOH extract of <i>G. schizopleura</i> through a series of chromatographic techniques. The structures of the new metabolites were established by analyses of their spectroscopic data (1D NMR, 2D NMR, HRESIMS and IR). All the isolated compounds <b>1</b>–<b>6</b> were tested against human promyelocytic leukaemia (HL-60), human colon adenocarcinoma (HT-29) and Mus musculus skin melanoma (B16-F10). Compound <b>1</b> and <b>2</b> showed active inhibition against HL-60 and B16-F10 cells.</p>