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Tumor-Homing Glycol Chitosan-Based Optical/PET Dual Imaging Nanoprobe for Cancer Diagnosis
journal contribution
posted on 2015-12-17, 01:05 authored by Sangmin Lee, Sun-Woong Kang, Ju Hee Ryu, Jin Hee Na, Dong-Eun Lee, Seung
Jin Han, Choong Mo Kang, Yearn Seong Choe, Kyo Chul Lee, James F. Leary, Kuiwon Choi, Kyung-Han Lee, Kwangmeyung KimImaging techniques including computed
tomography, magnetic resonance
imaging, and positron emission tomography (PET) offer many potential
benefits to diagnosis and treatment of cancers. Each method has its
own strong and weak points. Therefore, multimodal imaging techniques
have been highlighted as an alternative method for overcoming the
limitations of each respective imaging method. In this study, we fabricated
PET/optical activatable imaging probe based on glycol chitosan nanoparticles
(CNPs) for multimodal imaging. To prepare the dual PET/optical probes
based on CNPs, both 64Cu radiolabeled DOTA complex and
activatable matrix metalloproteinase (MMP)-sensitive peptide were
chemically conjugated onto azide-functionalized CNPs via bio-orthogonal
click chemistry, which was a reaction between azide group and dibenzyl
cyclooctyne. The PET/optical activatable imaging probes were visualized
by PET and optical imaging system. Biodistribution of probes and activity
of MMP were successfully measured in tumor-bearing mice.
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- Biophysics
- Biochemistry
- Space Science
- Physical Sciences not elsewhere classified
- Cell Biology
- Pharmacology
- Biotechnology
- Environmental Sciences not elsewhere classified
- Chemical Sciences not elsewhere classified
- Science Policy
- Biological Sciences not elsewhere classified
- Mathematical Sciences not elsewhere classified
Keywords
glycol chitosan nanoparticlesalternative method64 Cu radiolabeled DOTAmultimodal imagingCancer DiagnosisImaging techniquesCNPpositron emission tomographyimaging methodactivatable matrix metalloproteinaseImaging Nanoprobeazide groupMMPmultimodal imaging techniquesresonance imagingimaging systemdibenzyl cyclooctyne
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