Troger's Base Molecular Scaffolds in Dicarboxylic Acid Recognition

Artificial receptors (<b>1</b>−<b>5</b>) have been designed and synthesized from simple precursors. The chain length selectivity studies of dicarboxylic acids within the cavities of new fluorescent Troger's base molecular frameworks (<b>1</b>−<b>3</b>) have been carried out with a critical examination of their role of rigidity as well as flexibility in selective binding in comparison to receptor <b>5</b>. The chiral resolution of the racemic Troger's base receptors (<b>1</b> and <b>2</b>) by chiral recognition with (+)- camphoric acid using hydrogen-bonding interactions has been studied.