Triglyceride accumulation inhibitory effects of new chromone glycosides from <i>Drynaria fortunei</i>

<div><p>Two new chromone glycosides, drynachromosides C (<b>1</b>) and D (<b>2</b>), along with five known chromones (<b>3</b>–<b>7</b>), were isolated from the rhizomes of <i>Drynaria fortunei</i>. The structures of the two new compounds were elucidated on the basis of physico-chemical property and spectroscopic data. Triglyceride (TG) accumulation inhibitory effects of the obtained chromones on 3T3-L1 cells were investigated. The results showed that <b>1</b>, <b>2</b> and <b>5</b> exhibited inhibitory activity on TG accumulation. Effects of compounds <b>1</b> and <b>2</b> on mRNA expression of PPARγ, C/EBPα and aP2 in 3T3-L1 cells were also investigated.</p></div>