Fig 4.tif (259.53 kB)
Trends in HIV-1 protease mutations in Puerto Rico from 2002 to 2011.
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posted on 2017-05-11, 18:07 authored by Lycely del C. Sepúlveda-Torres, Lavanya Rishishwar, Maria Luisa Rogers, Eddy Ríos-Olivares, Nawal Boukli, I. King Jordan, Luis A. Cubano(A) Normalized protease (PRO) mutation frequencies, color-coded as shown in the key, are shown for the 2002–2011 period. White boxes indicate an absence of PRO resistance mutations in any given year. PRO mutation frequency profiles are grouped using hierarchical clustering, revealing five distinct clusters. Mutation names are shown adjacent to the clustering plot. (B) Box-plot distributions of the normalized PRO mutation frequencies. Box-plots are color-coded using a rainbow scheme to visually distinguish the five PRO mutation frequency clusters.
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TRUGENEmulti-drug combination therapiesRTdrug resistance profiles184V10- year periodantiretroviral selection pressure63PUniversidad Central del Caribedrug resistance trendsOpenGene DNA Sequencing Systemdrug resistanceantiretroviral drug resistanceSpecific resistance mutationsHIVImmunoretrovirus Research Laboratoryantiretroviral drug therapy
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