ol902217q_si_001.pdf (22.23 MB)
Toward the Total Synthesis of Goniodomin A, An Actin-Targeting Marine Polyether Macrolide: Convergent Synthesis of the C15−C36 Segment
journal contribution
posted on 2009-11-19, 00:00 authored by Tomoyuki Saito, Haruhiko Fuwa, Makoto SasakiStereoselective convergent synthesis of the C15−C36 segment of goniodomin A, an actin-targeting marine polyether macrolide natural product, has been achieved. The present synthesis features palladium(0)-catalyzed, copper(I)-mediated Liebeskind−Srogl cross-coupling as the fragment assembly process.