ol026046+_si_001.pdf (257.49 kB)
Toward the Combinatorial Synthesis of Polyketide Libraries: Asymmetric Aldol Reactions with α-Chiral Aldehydes on Solid Support
journal contribution
posted on 2002-06-22, 00:00 authored by Ian Paterson, Taoues Temal-LaïbThe viability of performing stereocontrolled aldol additions with α-chiral aldehydes attached by a silyl linker to a hydroxymethylpolystyrene
resin is demonstrated for boron and titanium enolates. Subsequent ketone reduction and manipulation on the solid support leads to elaborate
stereopentad sequences, as occur in 6-deoxyerythronolide B and discodermolide.