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Total Synthesis of Rugulovasine A

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journal contribution
posted on 2013-07-19, 00:00 authored by Yu-An Zhang, Qiang liu, Chao Wang, Yanxing Jia
A concise total synthesis of rugulovasine A is achieved by using Uhle’s ketone derivative as the key intermediate, which was synthesized by intramolecular cyclization via metal–halogen exchange. Two different routes to construct a spirocyclic butyrolactone subunit involving a Ru-catalyzed cyclocarbonylation and a special Ru-catalyzed double bond rearrangement were studied.

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