ol401541t_si_001.pdf (2.94 MB)
Total Synthesis of Rugulovasine A
journal contribution
posted on 2013-07-19, 00:00 authored by Yu-An Zhang, Qiang liu, Chao Wang, Yanxing JiaA concise total synthesis of rugulovasine A is achieved by using Uhle’s ketone derivative as the key intermediate, which was synthesized by intramolecular cyclization via metal–halogen exchange. Two different routes to construct a spirocyclic butyrolactone subunit involving a Ru-catalyzed cyclocarbonylation and a special Ru-catalyzed double bond rearrangement were studied.