ol802600n_si_001.pdf (3.25 MB)
Total Synthesis of Pseudodehydrothyrsiferol
journal contribution
posted on 2009-02-05, 00:00 authored by Hideaki Hioki, Masatoshi Motosue, Yasuhiko Mizutani, Akira Noda, Tomoaki Shimoda, Miwa Kubo, Kenichi Harada, Yoshiyasu Fukuyama, Mitsuaki KodamaAn enantioselective total synthesis of pseudodehydrothyrsiferol has been accomplished. The synthetic sequence highlights formation of the highly strained tetrahydropyran C-ring by a Mitsunobu-type SN2 reaction with an oxygen nucleophile.