ml5b00241_si_002.cif (14.26 kB)
Total Syntheses and Biological Evaluation of (±)-Botryosphaeridione, (±)-Pleodendione, 4-epi-Periconianone B, and Analogues
dataset
posted on 2015-11-12, 00:00 authored by Kishor
L. Handore, Prakash D. Jadhav, Bibhabasu Hazra, Anirban Basu, D. Srinivasa ReddyThe total syntheses of (±)-botryosphaeridione, (±)-pleodendione,
(±)-hoaensieremodione, 4-epi-periconianone B,
and their analogues have been accomplished for the first time. All
the synthesized target compounds were screened in neural anti-inflammatory
assays using LPS induced microglia cells (N9). Among them, compounds 1 and 21 were identified as potential lead compounds
for further profiling.
