Time-dependent changes in the stress-induced anxiety-like behaviors in rats as determined by OFT.

(A) Inner zone time, (B) outer zone time, (C) number of lines crossed in the first 30 seconds, and (D) total lines crossed in 1-, 4-, and 8-week stressed male rats, as determined by open field test (OFT). Numbers of animals are noted in parentheses. *p < 0.05 stress vs. control.