Time-dependent changes in the stress-induced anxiety-like behaviors in rats as determined by OFT.

<p>(A) Inner zone time, (B) outer zone time, (C) number of lines crossed in the first 30 seconds, and (D) total lines crossed in 1-, 4-, and 8-week stressed male rats, as determined by open field test (OFT). Numbers of animals are noted in parentheses. *<i>p</i> < 0.05 stress vs. control.</p>